Registration Dossier

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hexyloxyethanol
EC Number:
203-951-1
EC Name:
2-hexyloxyethanol
Cas Number:
112-25-4
Molecular formula:
C8H18O2
IUPAC Name:
2-(hexyloxy)ethanol
Details on test material:
n-hexylglykol
Purity: no data given

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
activated sludge, domestic
Details on inoculum:
activated sludge obtained from a waste water treating plant treating domestic sewage. Concentration 1 g/L dry substance.

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
30 min

Test conditions

Nominal and measured concentrations:
Nominal concentrations: 519, 775 and 1030 mg/L
Details on test conditions:
Preparation of test solutions:
per vessel: Test substance (either 63, 94, or 125 ml), synthetic medium 8 ml, inoculum 50, filled up with dionised water to a volume of 250 ml
Reference substance (positive control):
yes
Remarks:
3,5 dichlorophenole

Results and discussion

Effect concentrations
Duration:
30 min
Dose descriptor:
other: EC20
Effect conc.:
750 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Results with reference substance (positive control):
EC50 (30 min) = 15 mg/L

Applicant's summary and conclusion