3-phenylpropan-1-ol

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1968

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

publication including a sufficiently documented study description

Data source

Reference

Reference Type:

publication

Title:

Fundamental studies of safe compound perfumes for cosmetics, Part 1.

Author:

Takenaka, T., Hasegawa, E., Takenaka, U., Saito, F., Odaka, T.

Bibliographic source:

Preprint of Scientific Papers - The Fifth Congress of International Federation of Societies of Cosmetic Chemists, May 12-17, 1968, Tokyo, 313-329.

Materials and methods

Type of study / information:

in vivo

Endpoint addressed:

skin irritation / corrosion

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Closed patches were applied to the skin of the subjects (forearmes and inside of upper arms) from 24 to 48 hours and the results were read 30 minutes after removal.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-phenylpropan-1-ol

EC Number:

204-587-6

EC Name:

3-phenylpropan-1-ol

Cas Number:

122-97-4

Molecular formula:

C9H12O

IUPAC Name:

3-phenylpropan-1-ol

Method

Ethical approval:

not specified

Details on study design:

82 volunteers were treated with the test substance for 24-48 hours under occlusion. The test material concentration was 0.05 % - 0.5 %.
The following substances were used as a vehicle: ethanol or cream base containing squalen, lanoline, stearic acid, cetyl alcohol, polyoxyethylene cetylalcohol, preservatives, polyethylene glycol, d-sorbitol, citric acid and distilled water. Skin reactions were read 30 min after removal of the patch.

Details on exposure:

TYPE OF EXPOSURE MEASUREMENT: Exposure pads

EXPOSURE LEVELS: 0.05 % - 05 %

EXPOSURE PERIOD: 24 - 48 hours

POSTEXPOSURE PERIOD: 30 min

Results and discussion

Results:

No signs of skin irriation were found.

Applicant's summary and conclusion

Conclusions:

Tested on 82 volunteers, the test substance was not irritating to skin at concentrations of 0.05 - 0.5 %.

Executive summary:

In this publication the testing of several chemicals on the skin of human volunteers is described. The test substance was exposed to the skin sites under occlusion for 24 - 48 hours at a concentration of 0.05 - 0.5 % to 82 humans. As a result, no skin reactions were seen.