3-phenylpropan-1-ol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1971

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-phenylpropan-1-ol

EC Number:

204-587-6

EC Name:

3-phenylpropan-1-ol

Cas Number:

122-97-4

Molecular formula:

C9H12O

IUPAC Name:

3-phenylpropan-1-ol

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Housing: individually
- Diet: commercial diet ad libitum
- Water: ad libitum

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 240 cm2
- % coverage: 10
- Type of wrap if used: rubber sleeve covered with Webril padding

TEST MATERIAL
- Amount applied: 5000 mL/kg bw

Duration of exposure:

24 h

Doses:

5000 mL/kg bw

No. of animals per sex per dose:

6 animals

Control animals:

not required

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

< 5 000 mg/kg bw

Based on:

test mat.

Mortality:

4 of 6 animals died on days 1, 3 and 4.

Clinical signs:

other: No toxic signs were observed in the surviving animals during the 14 day observation period.

Gross pathology:

The lungs appeared hemorrhagic in 2 animals that had died, 1 animal had white nodules in the liver, in one female both ovaries appeared abscessed.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

In an acute dermal toxicity study the LD50 was found to be <5000 mg/kg bw.

Executive summary:

An acute dermal toxicity study was conducted on 6 New Zealand white rabbits. 5000 mL/kg bw were applied to the clipped skin sites under occlusion for 24 hours. After this exposure period, the animals were observed for 14 days. 2 rabbits died on day one and two further animals died on days 2 and 3. In two of this animals, the lungs were found to be hemorrhagic, one animal had white nodules in the liver and the ovaries of one female appeared abscessed. Clinical signs were not observed during the whole observation period in the surviving animals. Based on this result, the LD50 value was determined to be < 5000 mg/kg bw.