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Diss Factsheets

Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
November 21, 1990 - November 23 1990
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
Version / remarks:
1981
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3'-dicyclohexyl-1,1'-methylenebis(4,1-phenylene)diurea
EC Number:
406-370-3
EC Name:
3,3'-dicyclohexyl-1,1'-methylenebis(4,1-phenylene)diurea
Cas Number:
58890-25-8
Molecular formula:
C27 H36 N4 O2
IUPAC Name:
1-cyclohexyl-3-[4-({4-[(cyclohexylcarbamoyl)amino]phenyl}methyl)phenyl]urea
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): MDI/CHA
- Physical state: white yellowish solid
- Storage condition of test material: at room temperature in the dark

Results and discussion

Solubility in organic solvents / fat solubility
Key result
Medium:
standard fat
Remarks:
(HB 307)
Solubility:
< 1.8 mg/L
Temp.:
37 °C
Details on results:
Throughout the entire study period, solid test substance could be observed in the liquefied standard fat.

Applicant's summary and conclusion

Conclusions:
The solubility of the substance in standard fat HB 307 at 37°C was determined by visual observation. The fat solubility of the substance was determined to be < 1.8 mg/L at 37°C.