Registration Dossier
Registration Dossier
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EC number: 406-370-3 | CAS number: 58890-25-8 MDI/CHA
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In a 3 h activated sludge respiration inhibition study conducted according to OECD guideline 209, microorganisms in activated sludge were exposed to MDI/CHA. The EC50 and EC10 were >100 mg/L based on nominal concentrations. The study is considered to be reliable without restrictions. However, due to the very low water solubility (<1 mg/L), concentration levels that might be toxic to aerobic bacteria could not be reached.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
In a 3 h activated sludge respiration inhibition study conducted according to OECD guideline 209, microorganisms in activated sludge were exposed to MDI/CHA at the following nominal concentrations (limit test): 0 (blank control) and 100 mg/L (loading rate). The EC50 and EC10 were >100 mg/L based on nominal concentrations. The study is considered to be reliable without restrictions. However, due to the very low water solubility (<1 mg/L), concentration levels that might be toxic to aerobic bacteria could not be reached.
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