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EC number: 204-559-3 | CAS number: 122-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Article in foreign language (Japanese). Basic information obtained from the english translated summary and tables.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on Compoxinded Perfumes for Toilet Goods. On the Non-irritative Compounded Perfumes for Soaps
- Author:
- Tetsuya Fujii , Saburö Furukawa and Seiji Suzuki
- Year:
- 1 972
- Bibliographic source:
- Yukugaku 21(12), 904-908
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two different closed patch test were conducted on healthy male and female subjects. For the first closed patch test, the small of back of 34 subjects were treated with 20% test substance in vaselinum aldum or unguentum hydrophilicum for 48 hours. In the second closed patch test, 2% test substance was applied on the upper inside of arm of 30 subjects for 24-72 hours. Unguentum simplex and unguentum hydrophilicum served as vehicle.
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzyl propionate
- EC Number:
- 204-559-3
- EC Name:
- Benzyl propionate
- Cas Number:
- 122-63-4
- Molecular formula:
- C10H12O2
- IUPAC Name:
- benzyl propanoate
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- - 34 humans (first test) and 30 humans (second test)
- SCORING SYSTEM:
Reactions were recorded according to the following criteria: (-) = No reaction [negative reaction]; (+/- ) = Slight Erythema [suspected positive reaction]; (+) = Erythema [positive reaction]; (++) = Erythema and Dropsical swelling [positive reaction]; (+++) = Erythema, Papules and Vesicles [positive reaction]. - Details on exposure:
- TYPE OF EXPOSURE: closed
EXPOSURE LEVELS: 20% or 2%
EXPOSURE PERIOD: 24-72 hours (first test), 48 hours (second test)
Results and discussion
- Results:
- No reactions (erythema) were observed at 20% and 2% of the test substance.
Applicant's summary and conclusion
- Conclusions:
- No irritant reactions were produced neither at concentration of 20% test substance nor at a dose of 2% test substance.
- Executive summary:
The publication described two closed patch tests which were conducted on healthy male and female subjects. For the 48 hour closed patch test, 34 subjects were treated with 20% test substance in vaselinum aldum or unguentum hydrophilicum on the small back. In addition, a 24- to 72 -hour closed patch test was conducted on 30 male and female subjects, with the test item at 2% in unguentum simplex or unguentum hydrophilicum. In both tests, no irritant reactions were produced in the subjects.
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