Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl propionate
EC Number:
204-559-3
EC Name:
Benzyl propionate
Cas Number:
122-63-4
Molecular formula:
C10H12O2
IUPAC Name:
benzyl propanoate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Doses:
2050, 2560, 3200, 4000 and 5000 mg/kg bw
No. of animals per sex per dose:
10
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 300 mg/kg bw
Based on:
test mat.
95% CL:
>= 3 030 - <= 3 570
Mortality:
2050 mg/kg bw: none
2560 mg/kg bw: 4/10
3200 mg/kg bw: 5/10
4000 mg/kg bw: 9/10
5000 mg/kg bw: 9/10
Clinical signs:
other: 2050 mg/kg bw: none all higher doses: lethargy, pilorection, tremors, chromodacryorrhea

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute oral toxicity study the LD50 was determined to be 3300 mg/kg bw in rats.
Executive summary:

The acute oral toxicity of the test item was determined in rats. The study was conducted with 10 rats per group. The test item was administered in doses of 2050, 2560, 3200, 4000 and 5000 mg/kg bw. The animals were observed for mortality and/or systemic effects for 14 days. Mortality was observed in doses from 2560 mg/kg bw onwards. Lethargy, pilorection, tremors, chromodacryorrhea were observed at doses from 2560 mg/kg bw onwards. The LD50 was determined to be 3300 mg/kg bw.