Benzyl propionate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Benzyl propionate

EC Number:

204-559-3

EC Name:

Benzyl propionate

Cas Number:

122-63-4

Molecular formula:

C10H12O2

IUPAC Name:

benzyl propanoate

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

no data

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Clinical signs:

other: none

Other findings:

Skin irritation: moderate redness in 1 of 5 animals

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

A LD50 value greater than 5000 mg/kg bw was determined in a dermal toxicity in rabbits after treatment with the test item.

Executive summary:

To assess the acute dermal toxicity potential of the test item, a study equivalent to OECD TG 402 was performed. Five rabbits were each incubated with the limit dose of 5000 mg/kg bw. No clinical signs and no mortality was observed. Moderate redness was observed in one animal.

Based on the results of this study, the LD50 value for acute dermal toxicity was determined to be greater than 5000 mg/kg bw.