Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1972
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Principles of method if other than guideline:
Test animals: rat
Number of animals: 10/dose
Sex: not specified
Doses: 4
Period of observation: 14 days post administration
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl acetate
EC Number:
203-121-9
EC Name:
Cinnamyl acetate
Cas Number:
103-54-8
Molecular formula:
C11H12O2
IUPAC Name:
cinnamyl acetate
Specific details on test material used for the study:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
1460, 2220, 3330 and 5000 mg/kg body weight
No. of animals per sex per dose:
10 animals per dose
Control animals:
not specified
Details on study design:
not specified
Statistics:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 3 300 mg/kg bw
Based on:
test mat.
95% CL:
> 2 900 - < 3 700
Mortality:
- 0 (1460 mg/kg)
- 1 (2200 mg/kg)
- 6 (3330 mg/kg)
- 10 (5000 mg/kg)
Clinical signs:
Slow respiration, lethargy, depression, coarse tremors in high doses, death overnight to 2 days
Body weight:
not specified
Gross pathology:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.
Conclusions:
The oral LD50 value of the test substance in rats was established as ca. 3300 mg/kg body weight.
Executive summary:

The purpose of this study was to assess the toxicity of the test substance when administered to rats in four oral doses. The test substance was administered orally to 10 rats per dose, at 1460, 2220, 3330 and 5000 mg/kg body weight.

17 animals died during the study. Slow respiration, lethargy, depression, coarse tremors in high doses, death overnight to 2 days were observed during the 14 days observational period.

The oral LD50 value of the test substance in rats was established as 3300 mg/kg body weight.