Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 283-952-1 | CAS number: 84776-27-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinchona officinalis, Rubiaceae.
Endpoint summary
Administrative data
Description of key information
The LD50 of the read across substance quinine for rats after oral application is 350.812 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 455.8 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no further data
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of quinine sulphate for rats is 455.8 mg/kg bw.
- Executive summary:
The acute toxicity of quinine sulphate was tested on rats after oral application. From the study it is shown, that the LD50 of quinine sulphate is 455.8 mg/kg bw. According to this, the LD50 of quinine for rats is 350.82 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 350.82 mg/kg bw
- Quality of whole database:
- There are no details on the method available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute toxicity of the read across substance quinine was tested on rats via oral route. From the study it is shown, that the LD50 is 350.82 mg/kg bw. We conclude that totaquine, which consists of 75% quinine, has a similar LD50 value.
Justification for classification or non-classification
The LD50 of the read across substance quinine of rats after oral application is 350.82 mg/kg bw. According to CLP 1272/2008 criteria for oral application, LD50 > 300 mg/kg bw and < 2000 mg/kg bw, quinine is considered as harmful, if swallowed and has to be classified in category 4. Therefore, we conclude that totaquina, which consists of 75% quinine, is also harmful, if swallowed and has to be classified in category 4, too.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
