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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Study period:
1995
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Predicting absorption of fragrance chemicals tlirougli human skin
Author:
JURIJ J. HOSTYNEK
Year:
1995
Bibliographic source:
J . Soc. Cosmet. Chem., 46, 221-229

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Potts and Guy fitted an equation to the experimental permeation coefficients (Kp) of a variety of molecular structures through human skin. This equation was based on molecular weight (MW) and the octanolwater partition coefficient (log P).
To identify a mathematical model predictive of the mostly unexplored skin penetration of fragrance chemicals, the Potts-Guy equation was tested here by correlating the published, measured Kp for 20 such compounds with predicted Kp values.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxybenzyl alcohol
EC Number:
203-273-6
EC Name:
4-methoxybenzyl alcohol
Cas Number:
105-13-5
Molecular formula:
C8H10O2
IUPAC Name:
(4-methoxyphenyl)methanol

Results and discussion

Percutaneous absorption
Key result
Parameter:
rate
Absorption:
0.002 cm/h

Applicant's summary and conclusion

Conclusions:
In this publication an experimental permeability coefficient (Kp) of 1.65E-3 cm/h available from literature is indicated.
Executive summary:

In this study the validity of the Pott-Guy algorithm was tested. Therefore, a experimental permeability coefficient determined with human skin under steady state conditions from aqueous solution is available from literature and indicated in this study. The Kp value of the test item is 1.65E-3 cm/h.