Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Remarks:
Toxicokinetic assumption
Type of information:
other: Toxicokinetic assumption
Adequacy of study:
other information
Study period:
Assumption based on data which are compiled in the IUCLID data base
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The statement is based on toxicological data and not on a toxicokinetic study.

Data source

Reference
Reference Type:
other: information/assumption regarding toxicokinetic based on tocicological data
Title:
Unnamed
Year:
2015

Materials and methods

Objective of study:
other: information/assumption on toxicokinetics based on toxicological data
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
There are no experimental toxicokinetic data with 2,2-dimethylpropane-1,3-diyldibenzoate available. The following remarks on toxicokinetics of 2,2-dimethylpropane-1,3-diyldibenzoate are therefore based on the available studies which were compiled in the respective IUCLID database.
These assumptions follow the procedure indicated in chapter R.7c of the ECHA “Guidance on information requirements and chemical safety assessment” (version 3.0, November 2017).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-dimethylpropane-1,3-diyl dibenzoate
EC Number:
224-081-9
EC Name:
2,2-dimethylpropane-1,3-diyl dibenzoate
Cas Number:
4196-89-8
Molecular formula:
C19H20O4
IUPAC Name:
3-(benzoyloxy)-2,2-dimethylpropyl benzoate
Specific details on test material used for the study:
2,2-Dimethylpropane-1,3-diyl dibenzoate is a white to yellowish solid with mild odor. Its molecular weight is 312 g/mol. Its melting point is about 46.5°C at 1017 hPa and the boiling point is >300°C at 1004 hPa. 2,2-Dimethylpropane-1,3-diyl dibenzoate is not inhalable, because it is a wax with a low vapor pressure estimated to be < 0.0001 hPa at 25°C. The water solubility is 1.16 mg/l at 20 °C. The octanol-water partition coefficient (log Kow) of 2,2-dimethylpropane-1,3-diyl dibenzoate was determined to be 4.7 at 25°C and pH 7.
Radiolabelling:
no

Test animals

Species:
other: information/assumption on toxicokinetics based on toxicological data
Strain:
other: information/assumption on toxicokinetics based on toxicological data
Details on test animals or test system and environmental conditions:
information/assumption on toxicokinetics based on toxicological data

Administration / exposure

Route of administration:
other: information/assumption on toxicokinetics based on toxicological data
Vehicle:
other: information/assumption on toxicokinetics based on toxicological data
Details on exposure:
information/assumption on toxicokinetics based on toxicological data
Duration and frequency of treatment / exposure:
information/assumption on toxicokinetics based on toxicological data
Doses / concentrations
Remarks:
Doses / Concentrations:
information/assumption on toxicokinetics based on toxicological data
Details on study design:
information/assumption on toxicokinetics based on toxicological data

Results and discussion

Main ADME resultsopen allclose all
Type:
other: toxicokinetics
Results:
Specific investigations are not available. The available statements refer to physico-chemial and toxicological data.
Type:
absorption
Results:
Absorption via oral, dermal or inhalation route is anticipated to be low.
Type:
distribution
Results:
The available studies on acute and repeated dose toxicity do not provide information on distribution
Type:
metabolism
Results:
No data available. From results of the in vitro genotoxicity tests it can be assumed that DNA reactive metabolites will most propabely not be generated in mammals in the course of hepatic biotransformation.
Type:
excretion
Results:
No data available. In general the major routes of excretion of an organic compound from the systemic circulation are the urine and/or feces.

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Executive summary:

Specific investigations are not available. The available statements refer to physico-chemical and toxicological data. Absorption via oral, dermal or inhalation route is anticipated to be low. The available acute and repeated dose toxicity studies do not provide information on distribution. No metabolites are identified. From results of the in vitro genotoxicity tests it can be assumed that DNA reactive metabolites will most probably not be generated in the course of hepatic transformation. There is no information on excretion. In general the major routes of excretion of an organic compound from systemic circulation are the urine and / or faeces.