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EC number: 224-081-9 | CAS number: 4196-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to the Guideline of today, but without gross pathology and without GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2-dimethylpropane-1,3-diyl dibenzoate
- EC Number:
- 224-081-9
- EC Name:
- 2,2-dimethylpropane-1,3-diyl dibenzoate
- Cas Number:
- 4196-89-8
- Molecular formula:
- C19H20O4
- IUPAC Name:
- 3-(benzoyloxy)-2,2-dimethylpropyl benzoate
Constituent 1
- Specific details on test material used for the study:
- - yellowish white chunks
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-244 g
- Fasting period before study: diet was withheld for up to 18 hours before doseing
- Housing: in groups of 5
- Diet ad libitum
- Water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- temperature and humidity controlled quarters
- The animals were maintained in accordance with the recommendations contained in H.E.W. Publication No.74-23 (N.I.H.) entitled "Guide for the care and use of laboratory animals"
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test material was administered orally by gavage as a suspension in corn oil. The dosage was administered at a volume of 20 ml/kg.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- 5 males and 5 females were used in this study. The test material was administered orally by gavage as a suspension in corn oil. The dosage level was administered at a volume of 20 mg/kg. Observations for toxic signs were recorded during the first 4 hours following dosing, at 24 hours and daily thereafter for a total of 14 days. The rats were observed for mortality, clinical signs and body weight development.
- Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: No rat died. All rats showed weight gain. Some rats developed hypoactivity, urine stained abdomen and diarrhea, but returned to normal within the 14 day observation period.
- Mortality:
- No rat died.
- Clinical signs:
- other: Some rats developed hypoactivity, urine stained abdomen and diarrhea, but returned to normal within the 14 day observation period.
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Five male and 5 female Sprague-Dawley rats received a single dose of 5000 mg/kg bw. The rats were observed for mortality, clinical signs and body weight development. No rat died. The discriminating dose is 5000 mg/kg bw.
- Executive summary:
5 male and 5 female Sprague-Dawley rats were used to examine the acute oral toxicity in a study similar to the Guideline of today. There is no information on GLP and or gross pathology. 5000mg/kg bw of the test material was administered orally by gavage as a suspension in corn oil. The dosage level was administered at a volume of 20 ml/kg. Observations for pharmacotoxic signs were recorded during the first 4 hours following dosing, at 24 hours and daily thereafter for a total of 14 days. The rats were observed for mortality, clinical signs and body weight development. No rat died. All rats showed weight gain. Some rats developed hypoactivity, urine stained abdomen and diarrhea, but returned to normal within the 14 day observation period. Thus, the LD50 is > 5000 mg/kg bw.
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