Registration Dossier
Registration Dossier
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EC number: 931-313-9 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List IV
- Author:
- Smyth Jr. HF, Carpenter CP, Weil CS
- Year:
- 1 951
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med. 4, 119-122.
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene- CAS No: 764-41-0
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dermal LD50 has been determined with rabbits, after 24-hour dermal exposure under occlusive conditions. Method described in: Smyth et al., J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 1,4-dichlorobut-2-ene.
- Analytical purity: no data.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- no data
- No. of animals per sex per dose:
- 6 per dose group (sex of the animals not reported)
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Statistics:
- Standard deviations calculated by the method of Thompson (1947)
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 735 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 557 - 960
Applicant's summary and conclusion
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