Reaction mass of 1,4-dichlorobut-2-ene; 3,4-dichlorobut-1-ene

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment: method not according to today's standard. However, according to OECD SIDS a reliability of 1 was given.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1959

Report date:

1959

Reference 2

Reference Type:

secondary source

Title:

1,4-Dichlorobut-2-ene- CAS No: 764-41-0

Author:

OECD SIDS

Year:

2006

Bibliographic source:

SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

1 drop of a 1% solution in oil was instilled into conjunctival sack of one rabbit.

GLP compliance:

no

Remarks:

was not mandatory at the time of the study

Test material

Test material information

Constituent 1

Reference substance name:

1,4-dichlorobut-2-ene

EC Number:

212-121-8

EC Name:

1,4-dichlorobut-2-ene

Cas Number:

764-41-0

Molecular formula:

C4H6Cl2

IUPAC Name:

1,4-dichlorobut-2-ene

Details on test material:

- Name of test material (as cited in study report): 1,4-dichlorobut-2-ene.
- Analytical purity: no data .

Test animals / tissue source

Species:

rabbit

Test system

Amount / concentration applied:

Concentration: 1 %

Number of animals or in vitro replicates:

1

Results and discussion

In vivo

Results

Irritation parameter:

other: no data

Irritant / corrosive response data:

Effects: severe erythema and swelling of mucous membranes of the eyes.

Applicant's summary and conclusion

Interpretation of results:

highly irritating

Remarks:

Migrated information