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Diss Factsheets
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EC number: 931-313-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed. The test was considered invalid because of the following reasons: limited documentation; no guideline study, use of the crude material that could be possibly influence the irritant action of dichlorobutene.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene- CAS No: 764-41-0
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A 1 % solution of crude dichlorobutene in acetone was applied on the shaved skin of 10 guinea pigs.
- GLP compliance:
- no
- Remarks:
- GLP was mandatory at the time of the study
- Type of study:
- open epicutaneous test
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- Crude preparation A 9949 containing 20% cis-1,4-dichlorobut-2-ene, 45% trans-1,4-dichlorobut-2-ene, and 35% 3,4-dichlorobut-1-ene as well as 4% foreshots and 5% tails. Composition of foreshot: 80% dichlorobutenes and small amounts of alpha-, beta- and isochloroprene, crotyl chloride, 3-chlorobut-1-ene, dichloropropene, and 1,2-dichloro-2-methylpropane. Composition of tails: 50% dichlorobutenes and small amounts of trichlorobutene, tetrachlorobutane, and a C8 chloro compound.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- 1% of crude dichlorobutene in acetone was applied during the induction exposure. First challenge: 1% solution. Second challenge: 10% solution.
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone
- Concentration / amount:
- 1% of crude dichlorobutene in acetone was applied during the induction exposure. First challenge: 1% solution. Second challenge: 10% solution.
- No. of animals per dose:
- 10
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
Series of 6 sensitizing treatments were performed over a period of 2 weeks (1% of crude dichlorobutene in acetone was applied during the induction exposure). Afterwards the animals were allowed to rest for 2 weeks.
B. CHALLENGE EXPOSURE
After 2 weeks the animals were challenged by the application of a drop of a 1 % solution of dichlorobutene in acetone. A week later the animals were challenged by application of a drop of a 10 % solution of dichlorobutene in acetone.
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 1%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 1%. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 10%
- No. with + reactions:
- 10
- Total no. in group:
- 10
- Clinical observations:
- strongly and developed erythema
- Remarks on result:
- other: Reading: rechallenge. . Hours after challenge: 24.0. Group: test group. Dose level: 10%. No with. + reactions: 10.0. Total no. in groups: 10.0. Clinical observations: strongly and developed erythema .
Any other information on results incl. tables
When a 1 % solution of crude dichlorobutene in acetone was applied on the shaved skin of 10 guinea pigs, 3/10 animals reacted within 24 hours with a mild erythema. After a series of 6 sensitizing treatments over a period of 2 weeks the animals were allowed to rest for 2 weeks and then were challenged by the application of a drop of a 1 % solution of dichlorobutene in acetone. The response was negative. A week later the animals were challenged by application of a drop of a 10 % solution of dichlorobutene in acetone. All 10 guinea pigs reacted strongly and developed erythema within 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
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