(E)-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-2-buten-1-one

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From July 25 to 31, 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

Regulation (EC) N°440/2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP compliance programme (inspected on March 12 to 14, 2014 / signed on May 12, 2014)

Type of method:

gas saturation method

Key result

Temp.:

25 °C

Vapour pressure:

3.2 Pa

Results of the vapor pressure determinations

Saturator Column.	Temperature (°C)	Volume* V (mL)	Mass of test item in Trap 1 (µg)	Mass of test item in Trap 2 (µg)	Total mass of test item (µg)	Vapor pressure (Pa)	Average Vapor pressure [Pa] (Std Dev)
A	25	8383	2109.750	6.543	2116.293	3.25	3.26 (1.79 * 10^-2)
B		11177	2183.850	3.331	2817.181	3.25
C		13972	3554.050	3.578	3557.628	3.28
A	35	6092	3524.100	2.717	3526.817	7.71	7.77 (0.124)
B		8123	4677.505	3.123	4680.173	7.68
C		10153	6019.500	7.186	6026.686	7.91
A	45	4263	5554.500	4.255	5558.755	17.9	18.0 (0.269)
B		5684	7338.500	3.702	7342.202	17.8
C		7105	9447.000	2.978	9449.978	18.3

                                                                                                                                             

*Corrected volume at test temperature as calculated under “Volume correction” 

                                     

Validation

The linearity of the detector response with respect to concentration was assessed over the concentration range of 1.07 to 1.07 X 10³ mg/L (n = 7). The results were satisfactory with a correlation coefficient of 1.000 being obtained.

The concentrations in the sample solutions from traps 1 ranged between 42.2 and 189 mg/L, and therefore, were within the calibration range. For traps 2 (0.05 —0.14 mg/L), inaccuracy in the determination is considered negligible as this collected fraction represents less than 0.5% of the total amount.

Conclusions:

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).

Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method.

Determinations were conducted at 25, 35 and 45 °C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapor pressure at 25 °C was interpolated from the regression.

The vapor pressure of the test item has been determined to be 3.2 Pa at 25 °C.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:

3.2 Pa

at the temperature of:

25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data for purpose of CSA.