Nickel dihydroxide

Toxicity to other aquatic organisms

Administrative data

Endpoint:

toxicity to other aquatic vertebrates

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Peer reviewed data, acceptable for assessment.

Data source

Reference

Reference 1

Reference Type:

secondary source

Title:

SIDS Initial Assessment Profile on Nickel and Nickel Compounds-Draft SIAR

Author:

OECD

Year:

2007

Bibliographic source:

SIDS Dossier -Draft

Reference 2

Reference Type:

publication

Title:

Teratogenicity of Ni2+ in Xenopus laevis, assayed by the FETAX procedure.

Author:

Hopfer SM, Plowman MC, Sweeney KR, Bantle JA, Sunderman FW.

Year:

1991

Bibliographic source:

Biol. Trace Elem. Res. 29: 203-215. cited in SIDS

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The standard Fetax procedure was performed using embryos at the blastula stage.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Nickelchloride

IUPAC Name:

Nickelchloride

Constituent 2

Reference substance name:

Nickel dichloride

EC Number:

231-743-0

EC Name:

Nickel dichloride

Cas Number:

7718-54-9

IUPAC Name:

nickel(2+) dichloride

Sampling and analysis

Analytical monitoring:

not specified

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Xenopus laevis

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Test conditions

Hardness:

Hardness was not reported
but standard Fetax assay recommended a hardness of 100 mg/l.

Test temperature:

23 °C

Nominal and measured concentrations:

The assay was repeated 7 times using 22 different concentrations ranging from 5.9 μg/l to 176 mg/l Ni.

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

4 d

Dose descriptor:

LC10

Effect conc.:

13.1 mg/L

Conc. based on:

element

Remarks:

Ni

Basis for effect:

mortality

Effect concentrations 2

Duration:

4 d

Dose descriptor:

LC10

Effect conc.:

0.085 mg/L

Conc. based on:

element

Remarks:

Ni

Basis for effect:

other: Malformation

Effect concentrations 3

Duration:

4 d

Dose descriptor:

LC10

Effect conc.:

20.69 mg/L

Conc. based on:

other: Nickeldihydroxid

Basis for effect:

mortality

Remarks on result:

other: Result calculated for Nickeldihydroxid

Effect concentrations 4

Duration:

4 d

Dose descriptor:

LC10

Effect conc.:

0.13 mg/L

Conc. based on:

other: Nickeldihydroxid

Basis for effect:

other: Malformation

Remarks on result:

other: Result calculated for Nickeldihydroxid