Registration Dossier
Registration Dossier
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EC number: 235-008-5 | CAS number: 12054-48-7
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review-Basic data given but only summary available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- NICKEL HAZARDS 10 FISH, WILDLIFE, AND INVERTEBRATES-A Synoptic Review
- Author:
- Ronald Eisler
- Year:
- 1 998
- Bibliographic source:
- U.S. Department of the Interior U.S. Geological Survey Patuxent Wildlife Research Center-Biological Science Report USGS/BRD/B SR-1 998-0001
- Reference Type:
- publication
- Title:
- Effects of dietary nickel on mallards
- Author:
- Eastin and O´Shea
- Year:
- 1 981
- Bibliographic source:
- Journal of Toxicology and Environmental Health 7: 883-892 cited in: NICKEL HAZARDS 10 FISH, WILDLIFE, AND INVERTEBRATES-A Synoptic Review
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Nickel
- EC Number:
- 231-111-4
- EC Name:
- Nickel
- Cas Number:
- 7440-02-0
- IUPAC Name:
- nickel(2+)
Constituent 1
- Dose method:
- feed
- Analytical monitoring:
- not specified
Test organisms
- Test organisms (species):
- Anas platyrhynchos
- Details on test organisms:
- TEST ORGANISM
- Common name: mallard
- Age at test initiation (mean and range, SD): 20 month old
- Breeding population: yes
Study design
- Limit test:
- no
- Total exposure duration (if not single dose):
- 90 d
- Nominal and measured doses / concentrations:
- 0, 12.5, 50, 200, or 800 mg Ni/kg
Results and discussion
Effect levelsopen allclose all
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 800 mg/kg diet
- Conc. / dose based on:
- element
- Remarks:
- Nickel
- Basis for effect:
- reproductive parameters
- Remarks:
- egg production and hatchability
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 800 mg/kg diet
- Conc. / dose based on:
- element
- Remarks:
- Nickel
- Basis for effect:
- mortality
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 1 263.7 mg/kg diet
- Conc. / dose based on:
- other: Nickeldihydroxid
- Basis for effect:
- reproductive parameters
- Remarks:
- egg production and hatchability
- Remarks on result:
- other: Calculated for Nickeldihydroxid
- Duration (if not single dose):
- 90 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 1 263.7 mg/kg diet
- Conc. / dose based on:
- other: Nickeldihydroxid
- Basis for effect:
- mortality
- Remarks on result:
- other: Calculated for Nickeldihydroxid
Any other information on results incl. tables
No effect on egg production, hatchability, or survival of ducklings; adults had normal blood chemistry and no organ histopathology.
Applicant's summary and conclusion
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