Registration Dossier
Registration Dossier
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EC number: 210-609-5 | CAS number: 619-67-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10.6.1997 - 26.6.1997
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-hydrazinobenzoic acid
- EC Number:
- 210-609-5
- EC Name:
- 4-hydrazinobenzoic acid
- Cas Number:
- 619-67-0
- Molecular formula:
- C7H8N2O2
- IUPAC Name:
- 4-hydrazinylbenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 72 h
- Observation period (in vivo):
- 1, 24, 48, 72 h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- animal #1
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- >= 0 - <= 10
- Max. score:
- 10
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #2
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- >= 0 - <= 13
- Max. score:
- 13
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- animal #3
- Time point:
- other: 1, 24, 48, 72 h
- Score:
- >= 0 - <= 17
- Max. score:
- 17
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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