Registration Dossier
Registration Dossier
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EC number: 264-129-6 | CAS number: 63405-85-6
Endpoint summary
Administrative data
Description of key information
Short-term toxicity tests are available for all the three tropic levels (fishes, invertebrates and aquatic plants). In an acute fish toxicity test, the test substance FAT 20004 was observed to have TL50 freshwater fish, Oncorhynchus mykiss ranging from 140 – 450 mg/L, Indicating the test substance to be not toxic (TL50>100 mg/L) to fish. In the Daphnia magna study no immobilization and abnormal behavior of the daphnids was observed in the controls and in the test concentration up to 10.0 mg test article (as the highest concentration as possible to dissolve in dimethylformamid at room temperature and an addition of 100 ul solvent stock solution to 1 litre test medium).The EC100 could not be determined. The EC 50 value after 24 and 48 hours could not be calculated, but was clearly higher than 10 mg/L. In conclusion the EC50 value of FAT 20004 was above the limit of solubility of the test substance in the test medium. The NOEC (highest concentration tested without toxic effect) of FAT20004/H was determined to be 10.0 mg test article/L. In a GLP-compliant OECD 201 guideline study green alga Scenedesmus subspicatus exposed to the test item FAT 20004 no inhibition at 10 mg/L the highest concentration tested. Due to the low inhibition rate in the concentration of 10 mg/L no EC 50-values could be calculated. The EC0 was therefore determined to be 5.0 mg test substance/L and the LOEC amounted to 10.0 mg test substance/L. Hence, LC50 is concluded to be greater than 100mg/L. In a study carried out to determine IC50 of FAT 20004/H according to GLP guideline 209, the IC50 value for FAT 20004 was found to be greater than 100 mg/L. Several other supporting studies were also performed the BST value for FAT 20004 was found to be greater than 300 & 200 mg/L. Hence, the IC50 of FAT 20004 was determined to be >100 mg/l. Based on these results the test substance, FAT 20004 can be regarded as not acute toxic to aquatic species.
Additional information
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