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EC number: 500-057-6 | CAS number: 27104-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 3/11/1994 and 17/11/1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in full compliance with OECD guideline. Exposure duration higher than 4h (at day-7, traces of remaining product found on the fur of all rabbits).
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Products found on the fur at day 7
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Products found on the fur at day 7
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 1994-03-16
Test material
- Test material form:
- other: liquid stored at room temperature
- Details on test material:
- - Physical state: liquid (pale straw-coloured liquid)
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source: David Percival Ltd, Moston, Sandbach, Cheshire, UK
-Age at study initiation : 12 to 16 weeks
-Weight at study initiation: 2.31 to 2.59 kg
-Housing: individually
-Diet: ad libitum
-Water: ad libitum
-Acclimation period: Minimum 5 days
ENVIRONMENTAL CONDITIONS
Temperature: 16 – 19°C
Humidity: 56 -65%
Air exchange rate: 15 per hour
Photoperiod: 12 hours light, 12 hours dark
IN-LIFE DATES: No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
VEHICLE: none - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 6 (4 male, 2 female)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm (approximately 6 square cm)
- % coverage: no data
- Type of wrap: gauze patch held in place with elasticated corset.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the treated site was removed by gently swabbing with cotton wool soaked with 74% industrial methylated spirits.
- Time after start of exposure: 4 hours
SCORING SYSTEM: The treated area was scored for erythema and oedema using a numerical system based on that described by Draize et al. (1959) and the primary dermal irritation index (PDII) was calculated.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: over 24 to 72 hours
- Score:
- ca. 2.2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days for 2 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: over 24 to 72 hours
- Score:
- ca. 1.7
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days for 2 animals
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: over 24 to 72 hours
- Score:
- 3.3
- Irritant / corrosive response data:
- See Table 7.3.1/1
2/6 animals showed corrosive effects (see Others efffects for more details) - Other effects:
- Well-defined erythema was noted at two treated skin sites one hour after patch removal. Small areas of green-coloured dermal necrosis were noted at these two treated skin sites at the 24, 48 and 72-hour observations. Slight oedema was noted at these two treated skin sites one hour after patch removal with slight to moderate oedema at the 24-hour observation and slight oedema at the 48 and 72-hour observations. Skin reactions prevented accurate evaluation of erythema and oedema at these two treated skin sites at the 7-day observation and at one site at the 14-day observation. Well-defined erythema surrounding other skin reactions was noted at these two treated skin sites at the 24, 48, 72-hour and 7-day observations. Small superficial scattered scabs were noted at these two treated skin sites at the 14-day observation. Scar tissue was noted at both sites at the 14-day observation. Glossy skin and reduced re-growth of fur were also noted at one treated skin site at the 14-day observation.
Very slight erythema was noted at four treated skin sites one hour after patch removal, with very slight to well-defined erythema at the 24, 48 and 72 hour observations. Very slight oedema was noted at four treated skin sites one hour after patch removal with very slight to slight oedema at the 24-hour observation. Very slight oedema was noted at two treated skin sites at the 48-hour observation and at one treated site at the 72-hour observation. Crust formation or desquamation was noted at four treated skin sites at the 7-day observation. Desquamation was noted at one treated skin site at the 14-day observation.
Any other information on results incl. tables
Table 7.3.1/1: Irritation data for each animal at each observation time up to removal of each animal from the test
|
Reversibility*: nc: not completely reversible
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, Tetrakis (hydroxymethyl) phosphonium chloride, oligomeric reactions with urea (THPC-urea) is classified in
Category 1C, H314 according to the CLP regulation (1272/2008) and as corrosive (C, R34) according th the Directive 67/548/EEC. - Executive summary:
In a primary dermal irritation study, young adult New Zealand White rabbits (4 males and 2 females) were dermally exposed to 0.5 mL of a water solution of Tetrakis (hydroxymethyl) phosphonium chloride, oligomeric reactions with urea (THPC-urea). Test sites were covered with a semi-occlusive dressing for 4 hours. Animals then were observed for 14 days. The skin reactions were assessedat 1,24, 48 and 72 hours, as well as 7, 10 and 14 days after removal of the dressing.The mean score was calculated across 3 scoring times; 24, 48 and 72 hours after patch removal, for each animal separately. It should be noted that on day-7 remaining traces of test material were observed on all animals; therefore, it was considered that exposure duration was higher than 4-h.
The mean score calculated for 24 -48 and 72 hours was 2.2 for erythema/ eschar and 1.7 for oedema. At the 14 -day observation, scar tissue and small superficial scattered scabs were noted in one female (the mean erythema score (24, 48 and 72 hours): 4 and the mean oedema score (24, 48 and 72 hours): 2) and scar tissue reduced re-growth of fur, glossy skin and small superficial scattered scabs were observed in one male (the mean erythema score (24, 48 and 72 hours): 4 and the mean oedema score (24, 48 and 72 hours): 2.3).
Given these results,Tetrakis (hydroxymethyl) phosphonium chloride, oligomeric reactions with urea (THPC-urea) is classified in Category1C, H314 (causes severe skin burns and eye damage) according to the CLP regulation (1272/2008) and as corrosive (C, R34) according to the Directive 67/548/EEC.
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