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EC number: 453-570-1
CAS number: 540734-22-3
Similar to OECD Guideline 203, GLP, key study, validity 2:96h-LC50 = 13.1 mg/L (95% CL: 11.1 - 15.6 mg/L), based on nominal concentrations.
One key study is available to assess the acute
toxicity of the substance to zebra fish (Brachydanio rerio). This study
was performed similar to OECD Guideline 203 with GLP statement. Based on
the results of the preliminary test, the definitive test was conducted
with the test concentrations of 5.0, 7.5, 11.2, 16.7 and 25.0 mg/L
(nominal concentrations). Concurrent water control group was performed
in parallel. The study was performed with a semi-static water renewal
The 96h LC50 was calculated as 13.1 mg/L
(nominal concentration), and the 95% confidence limit was 11.1 mg/L -
15.6 mg/L. The highest concentration without observed effect was 5.0
All validity criteria of the OECD Guideline
203 were not fulfilled as no information is available on the analytical
measurements. Based on the analytical measurements of the other aquatic
studies (algae and aquatic invertebrates) and that this study was
conducted in a semi-static system, there must be evidence that the
concentration of the substance has been satisfactorily maintained.
Therefore, this study is considered reliable with restrictions.
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