Registration Dossier
Registration Dossier
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EC number: 937-132-1 | CAS number: 960316-73-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (2001)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate
- EC Number:
- 937-132-1
- Cas Number:
- 960316-73-8
- Molecular formula:
- C11H10ClN3O3
- IUPAC Name:
- methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Methyl cellulose 1%
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- six female rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: No mortalities occurred at a dose level of 2000 mg/kg bw, therefore, a LD50 >5000 mg/kg bw was derived according to OECD TG 423
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A dose of 2000 mg kg body weight was tolerated by female rats without mortalities, effects on body weight development and gross pathological findings. Clinical signs such as decreased activity (6/6), hunched back (3/6), prone position (5/6), piloerection (2/6) and incoordination (4/6) were observed but were fully reversible within 24 hours post-administration of the test material. Based on the study results and according to EU classification criteria, the test substance is not to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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