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Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data available in public domain
Justification for type of information:
Data available in public domain
Qualifier:
according to guideline
Guideline:
other: refer principle below
Principles of method if other than guideline:
To determine half life of hydrolysis of test chemical 2,4,6-trichloroaniline at different pH 5, 7 and 9.
GLP compliance:
not specified
Specific details on test material used for the study:
-Name of the test material: 2,4,6-trichloroaniline
- Molecular formula: C6H4Cl3N
- Molecular weight: 196.464 g/mol
- Smiles notation: Nc1c(Cl)cc(Cl)cc1Cl
- InChl : 1/C6H4Cl3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
-Substance type: Organic
-Physical state: solid
Radiolabelling:
not specified
Analytical monitoring:
not specified
Details on sampling:
No data available
Buffers:
Buffers
- pH: 5, 7, 9
- Type and final molarity of buffer: acetate, phosphate and borate,
respectively
- Composition of buffer: 10-3 M
Estimation method (if used):
No data available
Details on test conditions:
Details on test conditions
TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: Stoppered volumetric flask
- Sterilisation method:
- Lighting: Absence of light; experiment was performed in dark
system closed/open: Closed
- Preparation of test medium: Three aqueous solutions of 2, 4, 6-trichloroaniline (30 mg/L) were separately buffered to pH 5, 7, and 9 (10-3 M acetate, phosphate and borate, respectively) and stored in stoppered volumetric flasks in the dark at room temperature.
Duration:
2 wk
Initial conc. measured:
30 mg/L
Number of replicates:
No data available
Positive controls:
not specified
Negative controls:
not specified
Statistical methods:
No data available
Preliminary study:
No data available
Test performance:
No data available
Transformation products:
not specified
Details on hydrolysis and appearance of transformation product(s):
No data available
Key result
DT50:
> 12 d
Type:
not specified
Remarks on result:
other: at pH 5, 7 and 9
Other kinetic parameters:
No data available
Details on results:
No data available
Validity criteria fulfilled:
not specified
Conclusions:
2, 4, 6 Trichloroaniline is stable over a period of 2 weeks under ambient conditions in the absence of light. Therefore it can be concluded that half life of hydrolysis of test chemical 2,4,6-trichloroaniline is > 12 days. This half life of hydrolysis value indicates thet test chemical in not hydrolysable.
Executive summary:

Three aqueous solutions of 2,4,6-trichloroaniline (30 mg/L) were separately buffered to pH 5, 7, and 9 (10- M acetate, phosphate and borate respectively) and stored in stoppered volumetric flasks in the dark at room temperature.

Ultraviolet scans on the day of preparation and at intervals of 1 and 2 weeks showed no significant changes.

This indicates that 2,4,6-TCA in water is not hydrolyzed over a 2-week period under ambient conditions in the absence of light and half life of hydrolysis of test chemical 2,4,6-trichloroaniline is > 12 days.

Description of key information

2, 4, 6 Trichloroaniline is stable over a period of 2 weeks under ambient conditions in the absence of light. Therefore it can be concluded that half life of hydrolysis of test chemical 2,4,6-trichloroaniline is > 12 days. This half life of hydrolysis value indicates thet test chemical in not hydrolysable.

Key value for chemical safety assessment

Additional information

The half life of hydrolysis of test chemical was determined by performing an experiment in this the three aqueous solutions of 2,4,6-trichloroaniline (30 mg/L) were separately buffered to pH 5, 7, and 9 (10- M acetate, phosphate and borate respectively) and stored in stoppered volumetric flasks in the dark at room temperature.

Ultraviolet scans on the day of preparation and at intervals of 1 and 2 weeks showed no significant changes.

This indicates that 2,4,6-TCA in water is not hydrolyzed over a 2-week period under ambient conditions in the absence of light andhalf life of hydrolysis of test chemical 2,4,6-trichloroaniline is > 12 days.