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Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of test chemical was performed in rodents.
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
review article or handbook
Title:
Acute oral toxicity study of test chemical was performed in rodents.
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of test chemical was performed in rodents.
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
Reference Type:
secondary source
Title:
Acute oral toxicity study of test chemical was performed in rodents.
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of test chemical was performed in rodents.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-trichloroaniline
EC Number:
211-219-8
EC Name:
2,4,6-trichloroaniline
Cas Number:
634-93-5
Molecular formula:
C6H4Cl3N
IUPAC Name:
2,4,6-trichloroaniline
Details on test material:
- Name of test material: 2,4,6-trichloroaniline
- Molecular formula : C6H4Cl3N
- Molecular weight : 196.464 g/mol
- Substance type: Organic
- Physical state: Solid
Specific details on test material used for the study:
- Name of test material: 2,4,6-trichloroaniline
- Molecular formula : C6H4Cl3N
- Molecular weight : 196.464 g/mol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
1180 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
Details on study design:
- Other examinations performed: clinical signs
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 180 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at dose 1180 mg/kg bw
Clinical signs:
other: In Clinical signs observations, behavioral changes in motor activity (specific assay); convulsions or effect on seizure threshold;Somnolence (general depressed activity) were seen.
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 1180 mg/kg bw,when mouse were treated with 2,4,6-trichloroaniline (634-93-5) orally.
Executive summary:

Acute oral toxicity study was performed in mouse using test chemical.50% mortality was observed at dose 1180 mg/kg bw. Hence,LD50 value was considered to be 1180 mg/kg bw,when mouse were treated with 2,4,6-trichloroaniline (634-93-5)orally.