Registration Dossier
Registration Dossier
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EC number: 252-488-1 | CAS number: 35285-69-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96h) = 6.4 mg/L for Danio rerio (OECD 203, full test), read-across
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6.4 mg/L
Additional information
No studies investigating the short-term toxicity of sodium propylparaben (CAS 35285-69-9) to fish are available. Therefore, toxicity data of the corresponding acid propylparaben (CAS 94-13-3) are used as read across.
This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have identical chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.
For the toxicity of the analogue read across substance propylparaben the following data are available:
The GLP study was conducted under static conditions according to OECD 203 with Danio rerio (Kimmel, 2012a). Fish were exposed to nominal concentrations of 1.0, 2.2, 4.6, 10 and 22 mg/L resulting in measured concentrations of 23 mg/L, 8.2 mg/L and 3.4 mg/L. The lowest nominal test concentrations of 1.0 and 2.2 mg/L were not analysed, since these test concentrations were below the 96 h NOEC determined in this test. The LC50 (96h) was determined to be 6.4 mg/L and the NOEC (96h) was determined to be 3.4 mg/L.
Based on the similar chemical structure data on the source substance are considered to be also representative for the target substance.
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