Registration Dossier
Registration Dossier
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EC number: 604-384-6 | CAS number: 14384-34-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,3,4,9-tetrahydro-1H-carbazol-3-ol
- EC Number:
- 604-384-6
- Cas Number:
- 14384-34-0
- Molecular formula:
- C12H13NO
- IUPAC Name:
- 2,3,4,9-tetrahydro-1H-carbazol-3-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: adjacent untreated skin served as control
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 days
- Number of animals:
- Three rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- Erythema and Oedema
- Basis:
- mean
- Time point:
- other: 60 min
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Remarks:
- Erythema and Oedema
- Basis:
- mean
- Time point:
- other: 1 day
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Remarks:
- Erythema and Oedema
- Basis:
- mean
- Time point:
- other: 2 days
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Remarks:
- Erythema and Oedema
- Basis:
- mean
- Time point:
- other: 3 days
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- overall irritation score
- Remarks:
- Erythema and Oedema
- Basis:
- mean
- Time point:
- other: 4 days
- Score:
- 0
- Max. score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A single semi-occlusive application of the TS to intact rabbit skin for four hours elicited no dermal irritation.
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