Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 452-110-7 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
NA
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available genotoxicity data showing no mutagenic nor genotoxic activity of AAA reaction product, no classification applies in accordance to the cirteari in GHS/CLP regulations.
Additional information
No further experimental testing for carcinogenicity is considered scientifically justified based on exposure assessment, i.e. exposure based waiving (Adaption to column 2 - Annex XI section 3 "Substance-Tailored Exposure-Driven Testing"): AAA reaction product is only used in indistrial settings under conditions with very low potential human exposure (worker). No exposure to the general population. A full description of the exposure can be found in the attached CSR (section 13). In the CSR it is concluded that for all industrial uses, very low exposure levels are identified and RCRs below 1 compared to DNELs for systemic effects from long term exposure of 1.2 mg/m3 (inhalation) and 0.2 mg/kg bw/day (dermal). Any combination of uses will result in an RCR below 1. Workers will not be exposed at any critical level.
Supportive data form the available in vitro genotoxicity studies indicates no genotoxic activity, hence no carcinogenic potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
