Registration Dossier
Registration Dossier
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EC number: 288-342-9 | CAS number: 85711-80-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility (OECD 202), read across
Key value for chemical safety assessment
Additional information
Since no experimental studies investigating the short-term toxicity of 1,3-Propanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4) to aquatic invertebrates are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID Section 13.
The study with 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was performed, according to OECD Guideline 202 and GLP, in a static system, using Daphnia magna as test organism (Sewell and McKenzie, 2003). Daphnia magna was exposed to water accommodated fractions (WAF) with a loading rate of 1000 mg/L (nominal) for 48 h. The measured concentration was below the limit of quantification (i.e. < 0.032 mg/L). No effects were observed. Thus, an EL50 (48 h) >1000 mg/L based on the nominal concentration of the water accommodated fraction of the test substance was reported.
Based on the available results from this structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that 1,3-Propanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4) will not exhibit short-term effects on aquatic invertebrates up to the limit of water solubility.
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