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EC number: 457-630-8 | CAS number: 2138836-26-5
- Life Cycle description
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- Endpoint summary
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- Endpoint summary
- Stability
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
- Carcinogenicity
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- Specific investigations
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- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 11, 2005 to January 13, 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling schedule for chemical analysis: Samples were taken at 0 and 48 h
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus
- Sex: Parthenogenetic females
- Source: Strain of Bundesgesundheitsamt Berlin
- Age at study initiation: Neonates
- Food type: Green algae (Desmodesmus subspicatus)
- Frequency: Ad libitum
ACCLIMATION
A population of parthenogenetic females of synchronized age structure which had been maintained for more than 15 years in the test facility under constant temperature conditions (20±1°C) at a 16:8 h light-dark photoperiod (illumination: <1000 lux) were used in the study. The culture water (so-called 'M4 medium') was partly renewed once a week. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 228.48 mg CaCO3/L
- Test temperature:
- 18-22°C
- pH:
- Control: 8.2
Test: 8.2 - Dissolved oxygen:
- Control: 8.9 mg/L
Test: 9.0 mg/L - Nominal and measured concentrations:
- To prepare the only test concentration, 105.3 mg of the test substance were dissolved in 1 L of dilution water.
- Nominal concentration: 100 mg/L
- Measured concentration:
0 h = 99.66 mg/L
48 h = 98.07 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 50 mL glass beakers holding 10 neonates in 20 mL of test medium
- Aeration: None
- Type of system: Static
- No. of organisms per vessel: 10 neonates per vessel
- Biomass loading rate: 2 mL per neonate
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Feeding: No feeding during exposure period
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water ('M4 medium', originally described in Water Research 1990; 24 (9): 1157-1167), prepared according to the recommendations of Bundesgesundheitsamt Berlin
OTHER TEST CONDITIONS
- Photoperiod: 16 h light : 8 h dark
- Test concentrations: 100 mg/L (nominal) - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test conditions, the 48 h EC50 and NOEC of the test substance were >100 mg/L and 100 mg/L (nominal), respectively.
- Executive summary:
A limit test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to EU Method C.2 (equivalent or similar to OECD Guideline 202), in compliance with GLP.
In this test, 2 replicates of 10 Daphnia magna neonates were exposed to the substance at a nominal concentration of 100 mg/L under static conditions for 48 h. Immobility was recorded at 24 and 48 h.The analytical concentration of the test substance was measured by HPLC method and was found to be 99.7% of the nominal value at 0 h, and 98.1% of the nominal value at 48 h.
Under the test conditions, the 48 h EC50 and NOEC of the substance were >100 mg/L and 100 mg/L (nominal), respectively.
Reference
Table 1: EC50 of the test substance
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Description of key information
The 48-h EC50 and NOEC of the substance were >100 mg/L and ≥100 mg/L (nominal concentrations), respectively (Bruns, 2005).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
A limit test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to EU Method C.2 (equivalent or similar to OECD Guideline 202), in compliance with GLP. Two replicates of 10 Daphnia magna neonates were exposed to the substance at a nominal concentration of 100 mg/L under static conditions for 48 h. Immobility was recorded at 24 and 48 h. The analytical concentration of the test substance was measured by HPLC method and was found to be 99.7% of the nominal value at 0 and 98.1% of the nominal value at 48 h. Under the test conditions, the 48 h EC50 and NOEC were >100 mg/L and 100 mg/L (nominal), respectively (Bruns, 2005c).
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