Registration Dossier
Registration Dossier
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EC number: 685-515-4 | CAS number: 10309-37-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: An improved CAM Method for Predicting Ocular Irritation, Bagley, D.M., Rizvi, P.Y., Kong, B.M., and De Salva, S.J. (1988), Alternative Methods in Toxicology, Vol. 6, Progess in In Vitro Toxicology, pp. 131-138
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol
- EC Number:
- 685-515-4
- Cas Number:
- 10309-37-2
- Molecular formula:
- C18H24O
- IUPAC Name:
- 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol
Constituent 1
Test animals / tissue source
- Species:
- other: chorioallantoic membrane of White Leghorn eggs
- Details on test animals or tissues and environmental conditions:
- Pre-dose:
The eggs were placed in a commercial incubator at 99 ± 2℉ for 10 days.
Test system
- Vehicle:
- other: corn oil
- Controls:
- no
- Amount / concentration applied:
- concentration: 1%, 5%, 10%, 25%
dose: 40 μl - Duration of treatment / exposure:
- 30 ± 5 min
- Number of animals or in vitro replicates:
- 10 per concentration
Results and discussion
In vitro
Results
- Irritation parameter:
- other: RC50
- Remarks:
- %
- Value:
- ca. 7.7
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
Concentration (%) # of Eggs # of Positive Responses
1.0 10 0/10
5.0 10 2/10
10 10 7/10
25 10 10/10
The positive responses were characterized by capillary injection, hemorrhage and ghost vessels.
The RC50 and 95% Confidence Limits are 7.7 (5.7-10)%
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: RC50 > 3.0% = non-irritant
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