Registration Dossier
Registration Dossier
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EC number: 205-753-0 | CAS number: 150-13-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Link to relevant study records
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- GLP compliance:
- no
- Type of assay:
- in vitro mammalian chromosome aberration test
- Species / strain / cell type:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 1500/1700/1900 microgram/ml
- Vehicle / solvent:
- DMSO
- Untreated negative controls:
- no
- True negative controls:
- no
- Positive controls:
- yes
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- at the higest dose only
- Cytotoxicity / choice of top concentrations:
- not specified
- Conclusions:
- Interpretation of results (migrated information):
positive without metabolic activation
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Additional information
PABA did not induce mutations in bacteria, but induced an increased incidence of chromosome
aberrations in CHO cells at 1900 μg/ml (the highest dose tested; no scoreable metaphases could
be found at higher doses).
Justification for classification or non-classification
A classification for this endpoint is not required
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