Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: Directive 84/449 EEC, B4
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrasodium 5-[4-chloro-6-(N-ethyl-anilino)-1,3,5-triazin-2-ylamino]-4-hydroxy-3-(1,5-disulfonatonaphthalen-2-ylazo)-naphthalene-2,7-disulfonate
EC Number:
411-540-5
EC Name:
Tetrasodium 5-[4-chloro-6-(N-ethyl-anilino)-1,3,5-triazin-2-ylamino]-4-hydroxy-3-(1,5-disulfonatonaphthalen-2-ylazo)-naphthalene-2,7-disulfonate
Cas Number:
130201-57-9
Molecular formula:
C31H20ClN7Na4O13S4
IUPAC Name:
tetrasodium 5-[4-chloro-6-(N-ethyl-anilino)-1,3,5-triazin-2-ylamino]-4-hydroxy-3-(1,5-disulfonatonaphthalen-2-ylazo)-naphthalene-2,7-disulfonate

Test animals

Species:
rabbit
Strain:
New Zealand White

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal: No. 60, male
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal: No. 61, female
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
0
Irritation parameter:
erythema score
Basis:
animal: No. 62, female
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal: No. 60, male
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal: No. 61, female
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
0
Irritation parameter:
edema score
Basis:
animal: No. 62, female
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
0

Any other information on results incl. tables

SKIN IRRITATION SCORES

TIME PERIOD       ANIMAL    SEX       ERYTHEMA      EDEMA       CUMULATIVE  MEAN CUMULATIVE

                                                                             SCORE         SCORE

                                                                                                                 

1 HR.                60         M           0               0            0

               61         F           0               0            0

               62         F           0               0            0                0

24 HRS.              60         M           0               0            0

               61         F           0               0            0

                     62         F           0               0            0                0

48 HRS.              60         M           0               0            0

               61         F           0               0            0

                     62         F           0               0            0                0

72 HRS.              60         M           0               0            0

               61         F           0               0            0

                     62         F           0               0            0                0

Applicant's summary and conclusion

Interpretation of results:
other: not classified