Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: Directive 84/449 EEC, B5
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrasodium 5-[4-chloro-6-(N-ethyl-anilino)-1,3,5-triazin-2-ylamino]-4-hydroxy-3-(1,5-disulfonatonaphthalen-2-ylazo)-naphthalene-2,7-disulfonate
EC Number:
411-540-5
EC Name:
Tetrasodium 5-[4-chloro-6-(N-ethyl-anilino)-1,3,5-triazin-2-ylamino]-4-hydroxy-3-(1,5-disulfonatonaphthalen-2-ylazo)-naphthalene-2,7-disulfonate
Cas Number:
130201-57-9
Molecular formula:
C31H20ClN7Na4O13S4
IUPAC Name:
tetrasodium 5-[4-chloro-6-(N-ethyl-anilino)-1,3,5-triazin-2-ylamino]-4-hydroxy-3-(1,5-disulfonatonaphthalen-2-ylazo)-naphthalene-2,7-disulfonate

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Amount / concentration applied:
MG

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
animal: No. 57, male
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
>= 0 - <= 1
Irritation parameter:
overall irritation score
Basis:
animal: No. 58, male
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
>= 0 - <= 1
Irritation parameter:
overall irritation score
Basis:
animal: No. 59, female
Time point:
other: overall at 1, 24, 48 and 72 h
Score:
>= 0 - <= 1

Any other information on results incl. tables

EYE IRRITATION SCORES

ANIMAL SEX             CORNEA    IRIS    CONJUNCTIVAE       CUMULATIVE   MEAN CUMULATIVE

                           OPACITY            REDN.  CHEM.       SCORE          SCORE

                                                                                                                 

1 HR.

57       M NOT RINSED   0          0        0       1              1

58       M NOT RINSED   0          0        0       1              1

59       F NOT RINSED   0          0        0       1              1             1.00

24 HRS.

57       M NOT RINSED   0          0        0       1              1

58       M NOT RINSED   0          0        0       0              0

59       F NOT RINSED   0          0        0       1              1             0.67

         

48 HRS.             

57       M NOT RINSED   0          0        0       1              0

58       M NOT RINSED   0          0        0       0              0

59       F NOT RINSED   0          0        0       1              0             0.00

72 HRS.              

57       M NOT RINSED   0          0        0       1              0

58       M NOT RINSED   0          0        0       0              0

59       F NOT RINSED   0          0        0       1              0             0.00

Applicant's summary and conclusion

Interpretation of results:
other: not classified