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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
Justification for type of information:

1,6–divinylfluorohexane does not contain any functional group associated with hydrolysis properties.
The molecular structure of 1,6–divinylfluorohexane is characterized by a perfluorinated carbon chain with two vinyl groups at the far ends of the molecule.
The perfluorinated carbon chain is hydrolytically stable due to the presence of the carbon-fluorine bond, which is in fact one of the strongest bonds in organic chemistry (O’Hagan, 2007). Substitution of hydrogen atoms with fluorine results in increased bond strengths for both carbon-fluorine and adjacent carbon-carbon bonds over the corresponding hydrocarbon and it is expected to increase the resistance to hydrolysis.
The terminal vinyl groups are also not expected to undergo to significant (> 10%) hydrolisis in the condition of the preliminary test described in the OECD TG No. 111 (time = 5 days, pH = 4 to 9, Temperature = 50°C). The proximity with electronegative fluorine atoms makes the vinyl ends resistant to hydrolysis both at acid and basic pHs.
Pratical experience in the use of the substance confirms its abiotic stability at pH 4 to 9 and temperature up to 50°C.
Furthermore, there is evidence of its stability in basic condition (pH>9): its synthesis, in fact, involves as the final step the treatment of its precursor in ethanol/potassium ethylate (pH>9) at 70°C: no reaction occurs on just formed 1,6–divinylfluorohexane.
In conclusion, if tested with the standard OECD TG No. 111 method, B1,6–divinylfluorohexane would not show significant hydrolysis (> 10%) in the preliminary test, meaning that conducting the full study is not justified. The substance is therefore considered hydrolytically stable and its half-life at 25°C is estimated to be > 1 year.

Data source

Referenceopen allclose all

Reference Type:
Understanding organofluorine chemistry. An introduction to the C–F bond
Bibliographic source:
Chemical Society Reviews, vol. 37, no. 2, pp. 308-319.
Reference Type:
Explorations in fluorocarbon chemistry.
Lemal DM
Bibliographic source:
Abstracts of papers - American Chemical Society 2002-- 223():U556-U556

Materials and methods

Results and discussion

Applicant's summary and conclusion