Registration Dossier
Registration Dossier
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EC number: 217-288-0 | CAS number: 1800-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From July 2017 to August 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- - Appearance: Colourless liquid
- Test item storage: At room temperature protected from light
- Purity/Composition correction factor: No correction factor required - Radiolabelling:
- no
- Details on study design: HPLC method:
- - Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA)
- Detector Refractive Index detector 2414 (Waters)
- Column: Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 μm (Thermo Fisher Scientific, Waltham, MA, USA)
- Column temperature: 35°C +/- 1°C
- Injection: volume 10 μL
- Mobile phase: 55/45 (v/v) methanol/water
- Flow: 1.0 mL/min
- RI detection:
Temperature: 30°C
Sensitivity: 4
Time constant :1.0 seconds
Polarity :positive - Key result
- Type:
- log Koc
- Value:
- 4.3 dimensionless
- Type:
- Koc
- Value:
- 20 000 dimensionless
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: See table in "any other information on results"
- Details of fitted regression line (log k' vs. log Koc): The equation of the regression line was: log k’ = 0.370 x log Koc – 1.36 (r = 0.91, n = 16). - Validity criteria fulfilled:
- not applicable
- Conclusions:
- The organic carbon/water partition Koc of the test item at neutral pH was 20000 (log Pow = 4.30).
- Executive summary:
The organic carbon/water partition Koc of the test item was determined in a GLP-compliant study performed in accordance with EC C.19 Method and OECD Guideline No. 121, using the HPLC method. The organic carbon/water partition Koc of the test item at neutral pH was 2000 (log Koc = 4.30).
Reference
Koc HPLC Method
UPLC-UV chromatograms of the test item solution and corresponding blank are shown in the table below. In the chromatogram of the test solution, one major test item peak was observed.
Substance | Retention time (min) tr,1/ tr,2 |
Log Koc | Koc |
Formamide (t0) | 2.109 / 2.110 | ||
Acetanilide Monuron 2,5-Dichloroaniline Naphtalene Benzoic acid phenylester Fenthion Phenantrene 4,4'-DDT |
2.205 / 2.207 2.761 / 2.761 3.223 / 3.223 3.353 / 3.355 3.445 / 3.455 4.896 / 4.898 4.673 / 4.673 8.957 / 8.960 |
1.26 1.99 2.55 2.75 2.87 3.31 4.09 5.63 |
|
Test item - Peak 1 | 5.691 / 5.689 | 4.30 | 20000 |
Description of key information
The organic carbon/water partition Koc of the test item was determined in a GLP-compliant study performed in accordance with EC C.19 Method and OECD Guideline No. 121, using the HPLC method. The organic carbon/water partition Koc of the test item at neutral pH was 20000 (log Koc = 4.30).
Key value for chemical safety assessment
- Koc at 20 °C:
- 20 000
Additional information
The organic carbon/water partition coefficient Koc of the test item was determined in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
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