Registration Dossier
Registration Dossier
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EC number: 942-066-1 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28d) >= 100 mg/L (nominal, loading rate) for growth rate of Gobiocypris rarus (OECD 215, read across)
Key value for chemical safety assessment
Additional information
Since no study assessing the long-term toxicity of Reaction mass of bis(2-propylheptyl) hexanedioate and O6-[2,2-bis[[6-oxo-6-(2-propylheptoxy)hexanoyl]oxymethyl]butyl] O1-(2-propylheptyl) hexanedioate to fish is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the source substance Bis(2-propylheptyl) adipate (940-510-9, DPHA) was conducted. The read across is justified since DPHA is the main constituent (80%) of the target substance. The high molecular weight (> 900 g/mole) and log Pow (> 10) of the TMP ester constituent indicate a much lower toxicity of this constituent compared to DPHA. Thus, the study result for the source substance is considered to adequately cover the aquatic toxicity of the whole multi-constituent substance.
The long-term toxicity of the source substance Bis(2-propylheptyl) hexanedioate to freshwater fish was performed according to GLP and OECD guideline 215 using Gobiocypris rarus as test organism (BASF 2015). A 100 mg/L loading rate was tested as limit test. All validity criteria are fulfilled. No growth rate inhibition was observed in the treatment compared to the control. Thus, the 28d-NOEC value is determined to be >= 100 mg/L based on nominal concentration. Based on this result Reaction mass of bis(2-propylheptyl) hexanedioate and O6-[2,2-bis[[6-oxo-6-(2-propylheptoxy)hexanoyl]oxymethyl]butyl] O1-(2-propylheptyl) hexanedioate is considered to be not harmful to fish at chronic exposure.
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