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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Acute toxicity to fish:

The key study concerning the short-term toxicity of 3 -dimethylaminopropiononitrile (CAS 1738 -25 -6) to fish was performed as a guideline study according to DIN 38412 Part 15 with the test species Leuciscus idus (BASF AG, 1989, report no. 10F0143/885226).

The LC50 based on nominal test item concentrations was determined to be 681.2 mg/L (calculated as geometrical mean). At a test concentration of 464 mg/L no fish died, whereas a 100% mortality was observed in the next higher tested concentration of 1000 mg/L.

Long-term toxicity to fish:

There are no valid long-term toxicity results for fish available. Fish are not the most sensitive organisms. Therefore and for reasons of animal welfare, a long-term toxicity study in fish is not provided.

Acute toxicity to aquatic invertebrates:

An acute toxicity study was performed with Daphnia magna according to EU Method C.2 (BASF AG 1988, report no. 1/0947/2/88 -0947/88).

The reported nominal 48 -h EC50of the test substance on Daphnia magna was > 500 mg/L. This was the highest tested concentration and only 4 out of 20 animals were immobilized. Therefore, 3 -dimethylaminopropionitrile is considered to be with high probability acutely not harmful to aquatic invertebrates.

Long-term toxicity to aquatic invertebrates:

The hazard assessment of 3-dimethylaminopropiononitrile (CAS 1738-25-6) reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment. Therefore long-term toxicity testing on invertebrates is not provided.

Toxicity to aquatic algae:

In a 72-hour static test with the green alga Scenedesmus subspicatus according to the German Industrial Standard Test Guideline DIN 38412, the toxicity of 3 -dimethylaminopropionitrile in algae was investigated (BASF, 1989, report no. 01/88/0947). After 72 hours an EC50 of > 500 mg/L and an EC10 of 30.3 mg/L was estimated for the growth rate, related to the nominal concentration. Concerning observations of the biomass, the values are: EbC10 (72h): 10.2 mg/L, EbC50 (72h): 209.1 mg/L.

Toxicity to aquatic microorganisms:

As key study a non-GLP test according to German Industrial Standard DIN 38412 was performed using Pseudomonas putida as test organism. The EC10 (17h) was estimated to be 3432 mg/L and the EC50 was 4733 mg/L, both related to the nominal concentration (BASF AG 1989, report no. 9/0947/88/w). In addition, a respiration inhibition test according to ISO 8192 was conducted (BASF AG 1988, report no. 01.102). The EC10 (30 min) was determined to be > 1000 mg/L. However, the test was performed using industrial activated sludge and can therefore not be used for the derivation of the PNECstp.