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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Description of key information

Histopathologic changes in kidneys and bladder after acute oral application (175-700 mg/kg bw; Mumtaz et al. 1991)

Additional information

Oral administration of 175 - 700 mg dimethylaminopropionitrile/kg bw to rats twice within 24 hours leads to histopathological changes in the kidneys and bladder within a few hours (Mumtaz et al. 1991).