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Administrative data

Endpoint:
health surveillance data
Type of information:
other: survey
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication

Data source

Reference
Reference Type:
publication
Title:
Morbiditaetsstudie bei Mitarbeitern mit Exposition gegenüber Dimethylaminopropionitril (DMAPN)
Author:
Deckert H. et al.
Year:
1982
Bibliographic source:
Zbl. Arbeitsmed. 32 (1982) 5, 181-184

Materials and methods

Study type:
health record from industry
Endpoint addressed:
repeated dose toxicity: inhalation
neurotoxicity
Principles of method if other than guideline:
occupational health surveillance of workers exposed to DMAPN. Mobitty, illnesses, general health, clinical chemistry, haematology x-ray and EKG
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-dimethylaminopropiononitrile
EC Number:
217-090-4
EC Name:
3-dimethylaminopropiononitrile
Cas Number:
1738-25-6
Molecular formula:
C5H10N2
IUPAC Name:
3-(dimethylamino)propanenitrile

Method

Type of population:
occupational
Ethical approval:
not applicable
Details on study design:
34 workers of a DMAPN producing plant were examined as followed: anamnesis, general clinical examination, x-ray examination of the lung, electrocardiogram, clinical chemistry. The mean exposure time per worker was 9.35 years (1.1 to 33.4 years). Maximum room air concentrations per shift
0.007 to 0.024 ppm in the last 3 years before examination. Higher concentration may be supposed in former times

Results and discussion

Results:
Maximum room air concentrations per shift
0.007 to 0.024 ppm

Anamnesis
Nephrotic diseases were stated in 3/34 cases (pyelonephrolithiasis, recurrent infection of the urinary tract and hypertrophy of the prostata), but were not comparable to typical observed DMAPN effects. In one worker the urethral syndrome was detected.

General clinical examination
No typical symptoms found

X-ray examination of the lung
No pathological findings

Electrocardiogram
In 3/34 workers, weak dysfunction in neuronal conduction and exitation was observed. Effects were however not atributable dimethylpropioaminonitril.

in summary There were 12 medicinal findings in 9 of the 34 workersexamined. Findings correlate significantly with the age of the workeres but not with the exposure. In conclustion no effect related to Dimitylpropioaminonitril was foud in this study.

Clinical chemistry
No exposure-related findings

Any other information on results incl. tables

Room air concentrations in the years before 1977 should be considered higher than the concentrations measured here.

Signs of urinary retention, sexual dysfunction, urinary pain, insomnia, irritability, muscle weakness, paresthesias, which were observed in other studies, were not seen in this study.

Applicant's summary and conclusion

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