Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-090-4 | CAS number: 1738-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: review
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Classical Syndromes in Occupational Medicine: Dimethylaminopropionitrile
- Author:
- Keogh J.P.
- Year:
- 1 983
- Bibliographic source:
- American Journal of Industrial Medicine 4 :479-489 (1983)
- Reference Type:
- publication
- Title:
- Follow-up studies of workers with bladder neuropathy caused by exposure to dimethylaminopropionitrile
- Author:
- Baker E.L. et al.
- Year:
- 1 981
- Bibliographic source:
- Scand j work environ health 7 (1981): suppl 4, 54-59
- Reference Type:
- publication
- Title:
- An epidemic of urinary retention caused by dimethylaminopropionitrile
- Author:
- Keogh JP, Pestronk A, Wertheimer DS, Moreland R
- Year:
- 1 980
- Bibliographic source:
- J Am Med Assoc 243 :746-749
- Reference Type:
- publication
- Title:
- Neurologic dysfunction of the bladder in workers exposed to dimethylaminopropionitrile
- Author:
- Kreiss K, Wegman D, Niles CA, Siroky MB, Krane RJ, Feldman RG
- Year:
- 1 980
- Bibliographic source:
- J Am Med Assoc 243:741-745
- Reference Type:
- publication
- Title:
- Dimethylaminopropionitrile
- Author:
- Pestronk A, Keogh JP, Griffin JW
- Year:
- 1 980
- Bibliographic source:
- In Spencer PS, Schaumberg HH (eds) : "Experimental and Clinical Neurotoxicology ." Baltimore : Williams & Wilkins, pp 422-430
Materials and methods
- Type of study / information:
- Review of two epidemiological cases, description of findings and mechanism of toxicity
- Endpoint addressed:
- toxicity to reproduction / fertility
- neurotoxicity
- Principles of method if other than guideline:
- Review of two epidemiological cases, description of findings and mechanism of toxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-dimethylaminopropiononitrile
- EC Number:
- 217-090-4
- EC Name:
- 3-dimethylaminopropiononitrile
- Cas Number:
- 1738-25-6
- Molecular formula:
- C5H10N2
- IUPAC Name:
- 3-(dimethylamino)propanenitrile
Constituent 1
Method
- Ethical approval:
- not applicable
Results and discussion
- Results:
- Clinical presentation
Urinary retention was the predominant symptom in exposed workers (hesitancy, decreased stream, and the need to strain to pass urine). Impotence and decreased libido were the next most striking findings. Frequency of neurological symptoms (irritability, insomnia, muscle weakness and paresthesias in hands or feet) depends on exposure time. Most patients complained of difficulty in voiding as an initial complaint, followed by loss of libido and by insomnia and irritability. Nerve condition tests showed mild slowing in several patients. Blood and urine from patients showed no patterns of abnormalities.
Long-term effects
Two years after initial illness, there were persistent symptoms of urinary retention in 7 of 11 patients, loss of libido or impotence in 5, and weakness and paresthesias in 5. Three patients had signs of neurologic dysfunction in the lower extremities.
Sacral latencies had returned to normal in the three patients in which they had initially been prolonged. Two individuals had persisting abnormal cystometrograms. A number of individuals exposed in one of two studied plants had persisting symptoms of sexual and bladder dysfunction, irritability, and insomnia. While a majority of those exposed experienced prompt symptomatic recovery, some individuals had clearly permanent changes in bladder and peripheral nerve function.
Any other information on results incl. tables
Dimethylaminopropionitrile, used as a catalyst in the manufacture of polyurethane, was responsible for two epidemics of urinary retention, sexual dysfunction, and peripheral neuropathy in 1978. Most affected workers recovered promptly, but some have had persisting neuropathy, sexual and bladder dysfunction, and CNS symptoms.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
