Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is comparable to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975
Reference Type:
secondary source
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-dimethylaminopropiononitrile
EC Number:
217-090-4
EC Name:
3-dimethylaminopropiononitrile
Cas Number:
1738-25-6
Molecular formula:
C5H10N2
IUPAC Name:
3-(dimethylamino)propanenitrile
Details on test material:
- Name of test material (as cited in study report): N,N-Dimethyl-amino-propionitril
- Physical state: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
4640, 3160, 2150, 1470, 1000 µL/kg bw. (corresponding to ca. 3990 - 860 mg/kg bw; calculated with a density of 0.86 g/mL)
No. of animals per sex per dose:
2 (in the lowest and highest dose) or 5
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 290 mg/kg bw
Remarks on result:
other: original value: 1500 µl/kg, calculated with a density of 0.86 g/mL
Mortality:
1000 µL/kg bw: 0/4 animals
1470 µL/kg bw: 4/10 animals
all other animals treated with higher doses died
Clinical signs:
Dyspnoe, stretch/bend convulsions, tremor, tonic-clonic convulsions, apathy, abdominal/ lateral position, unusual noises, reddish salivation, bad general state
Gross pathology:
Animals that died: acute heart dilatation, congestion, hyperemia, stomach dilatated, partly diffuse reddened

Applicant's summary and conclusion

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