Registration Dossier
Registration Dossier
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EC number: 217-090-4 | CAS number: 1738-25-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is comparable to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-dimethylaminopropiononitrile
- EC Number:
- 217-090-4
- EC Name:
- 3-dimethylaminopropiononitrile
- Cas Number:
- 1738-25-6
- Molecular formula:
- C5H10N2
- IUPAC Name:
- 3-(dimethylamino)propanenitrile
- Details on test material:
- - Name of test material (as cited in study report): N,N-Dimethyl-amino-propionitril
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 4640, 3160, 2150, 1470, 1000 µL/kg bw. (corresponding to ca. 3990 - 860 mg/kg bw; calculated with a density of 0.86 g/mL)
- No. of animals per sex per dose:
- 2 (in the lowest and highest dose) or 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 290 mg/kg bw
- Remarks on result:
- other: original value: 1500 µl/kg, calculated with a density of 0.86 g/mL
- Mortality:
- 1000 µL/kg bw: 0/4 animals
1470 µL/kg bw: 4/10 animals
all other animals treated with higher doses died - Clinical signs:
- Dyspnoe, stretch/bend convulsions, tremor, tonic-clonic convulsions, apathy, abdominal/ lateral position, unusual noises, reddish salivation, bad general state
- Gross pathology:
- Animals that died: acute heart dilatation, congestion, hyperemia, stomach dilatated, partly diffuse reddened
Applicant's summary and conclusion
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