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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable with guideline study (inhalation hazard test described in the Annex of OECD Guideline 403)with acceptable restrictions (partly limited documentation)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
nominal atmosphere concentration determined by reweighing of the TS
GLP compliance:
no
Test type:
other: inhalation hazard test (IHT)
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-dimethylaminopropiononitrile
EC Number:
217-090-4
EC Name:
3-dimethylaminopropiononitrile
Cas Number:
1738-25-6
Molecular formula:
C5H10N2
IUPAC Name:
3-(dimethylamino)propanenitrile
Details on test material:
- Name of test material (as cited in study report): N,N-Dimethyl-amino-propionitril
- Physical state: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Mean weight at study initiation: 227 g

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Rats exposed for 3 h or 8 h, respectively, to a vapour saturated atmosphere.
Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Remarks on duration:
exposure to 3h was also studied
Concentrations:
5.72 mg/L nominal
No. of animals per sex per dose:
6
Control animals:
yes

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
other: IHT (inhalation hazard test)
Exp. duration:
8 h
Remarks on result:
other: mortality 1/12 after exposure to an atmosphere saturated with volatile compounds of the test substance (nominal 5.72 mg/L)
Sex:
male/female
Dose descriptor:
other: IHT (inhalation hazard test)
Exp. duration:
3 h
Remarks on result:
other: mortality 0/12 after exposure to an atmosphere saturated with volatile compounds of the test substance (nominal 5.12 mg/L)
Mortality:
3 h exposure: 0/12
8 h exposure: 1/12
Clinical signs:
other: Disturbance of equilibrium, strong secretion of eyes and nose, strong tremor.
Gross pathology:
Animals that died: acute heart dilatation, spotted hyperemia of the lung

Applicant's summary and conclusion

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