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EC number: 217-090-4 | CAS number: 1738-25-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable with guideline study (inhalation hazard test described in the Annex of OECD Guideline 403)with acceptable restrictions (partly limited documentation)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- nominal atmosphere concentration determined by reweighing of the TS
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test (IHT)
- Limit test:
- yes
Test material
- Reference substance name:
- 3-dimethylaminopropiononitrile
- EC Number:
- 217-090-4
- EC Name:
- 3-dimethylaminopropiononitrile
- Cas Number:
- 1738-25-6
- Molecular formula:
- C5H10N2
- IUPAC Name:
- 3-(dimethylamino)propanenitrile
- Details on test material:
- - Name of test material (as cited in study report): N,N-Dimethyl-amino-propionitril
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: 227 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- Rats exposed for 3 h or 8 h, respectively, to a vapour saturated atmosphere.
Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Remarks on duration:
- exposure to 3h was also studied
- Concentrations:
- 5.72 mg/L nominal
- No. of animals per sex per dose:
- 6
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: IHT (inhalation hazard test)
- Exp. duration:
- 8 h
- Remarks on result:
- other: mortality 1/12 after exposure to an atmosphere saturated with volatile compounds of the test substance (nominal 5.72 mg/L)
- Sex:
- male/female
- Dose descriptor:
- other: IHT (inhalation hazard test)
- Exp. duration:
- 3 h
- Remarks on result:
- other: mortality 0/12 after exposure to an atmosphere saturated with volatile compounds of the test substance (nominal 5.12 mg/L)
- Mortality:
- 3 h exposure: 0/12
8 h exposure: 1/12 - Clinical signs:
- other: Disturbance of equilibrium, strong secretion of eyes and nose, strong tremor.
- Gross pathology:
- Animals that died: acute heart dilatation, spotted hyperemia of the lung
Applicant's summary and conclusion
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