3-dimethylaminopropiononitrile

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable with guideline study (inhalation hazard test described in the Annex of OECD Guideline 403)with acceptable restrictions (partly limited documentation)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

nominal atmosphere concentration determined by reweighing of the TS

GLP compliance:

no

Test type:

other: inhalation hazard test (IHT)

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-dimethylaminopropiononitrile

EC Number:

217-090-4

EC Name:

3-dimethylaminopropiononitrile

Cas Number:

1738-25-6

Molecular formula:

C5H10N2

IUPAC Name:

3-(dimethylamino)propanenitrile

Details on test material:

- Name of test material (as cited in study report): N,N-Dimethyl-amino-propionitril
- Physical state: liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean weight at study initiation: 227 g

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Rats exposed for 3 h or 8 h, respectively, to a vapour saturated atmosphere.
Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Remarks on duration:

exposure to 3h was also studied

Concentrations:

5.72 mg/L nominal

No. of animals per sex per dose:

6

Control animals:

yes

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

other: IHT (inhalation hazard test)

Exp. duration:

8 h

Remarks on result:

other: mortality 1/12 after exposure to an atmosphere saturated with volatile compounds of the test substance (nominal 5.72 mg/L)

Effect levels 2

Sex:

male/female

Dose descriptor:

other: IHT (inhalation hazard test)

Exp. duration:

3 h

Remarks on result:

other: mortality 0/12 after exposure to an atmosphere saturated with volatile compounds of the test substance (nominal 5.12 mg/L)

Mortality:

3 h exposure: 0/12
8 h exposure: 1/12

Clinical signs:

other: Disturbance of equilibrium, strong secretion of eyes and nose, strong tremor.

Gross pathology:

Animals that died: acute heart dilatation, spotted hyperemia of the lung