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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data : List VI
Author:
Smyth Jr. H.F., Carpenter C.P., Weil C.S., Pozzani U.C., Striegel J.A., Striegel B.S.
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 23, 95-107

Materials and methods

Principles of method if other than guideline:
Penetration of rabbit skin is estimated by a technique closely akin to the one-day, cuff Method of Draize et al. (1944).
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-dimethylaminopropiononitrile
EC Number:
217-090-4
EC Name:
3-dimethylaminopropiononitrile
Cas Number:
1738-25-6
Molecular formula:
C5H10N2
IUPAC Name:
3-(dimethylamino)propanenitrile
Details on test material:
3-Dimethylaminopropionitrile, no further data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
4 males
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 213 mg/kg bw
Remarks on result:
other: original LD50 value: 1410 (880 - 2290) µL/kg bw (calculated with a density of 0.86 g/mL)

Applicant's summary and conclusion

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