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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: scientific review
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed data from the EU Risk Assessment Report for TCPP .

Data source

Reference
Reference Type:
publication
Title:
EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7,
Author:
EC
Year:
2008
Bibliographic source:
EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7, European Communities, May 2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-chloro-1-methylethyl) phosphate
EC Number:
237-158-7
EC Name:
Tris(2-chloro-1-methylethyl) phosphate
Cas Number:
13674-84-5
Molecular formula:
C9H18Cl3O4P
IUPAC Name:
tris(2-chloro-1-methylethyl) phosphate

Results and discussion

Any other information on results incl. tables

Dermal absorption:

The EU RAR adopts the worst case mean total dermal absorption value of 40 % for assessment of risks where skin exposure to TCPP is likely.

 

Oral absorption:

The EU RAR adopts the worst case mean total oral absorption value of 80 % for assessment of risks where oral exposure to TCPP is likely.

 

Inhalation absorption:

The EU RAR adopts the worst case mean total inhalation absorption value of 100 % for assessment of risks where inhalation exposure to TCPP is likely

 

Metabolism:

TCPP is rapidly metabolised (approx 98%) with main metabolites being 0,0-[Bis(1-chloro-2-propyl)]-0-(2-propionic acid)phosphate, bis(1- chloro-2-propyl)monophosphoric acid and 1-chloro-2-propanol.

Applicant's summary and conclusion