Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed data from the EU Risk Assessment Report for TCPP

Data source

Reference
Reference Type:
publication
Title:
EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7,
Author:
EC
Year:
2008
Bibliographic source:
European Communities, May 2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-chloro-1-methylethyl) phosphate
EC Number:
237-158-7
EC Name:
Tris(2-chloro-1-methylethyl) phosphate
Cas Number:
13674-84-5
Molecular formula:
C9H18Cl3O4P
IUPAC Name:
tris(2-chloro-1-methylethyl) phosphate

Test animals

Species:
other: rats and rabbits

Administration / exposure

Type of coverage:
not specified

Results and discussion

Any other information on results incl. tables

LD50 > 2000 mg/kg bw

Applicant's summary and conclusion

Conclusions:
In accordance with the CLP Regulation criteria, a substance is classified as to its acute dermal toxicity if LD50 ≤2 000 mg/kg bw.

The acute peer reviewed dermal toxicity LD50 data for TCPP in rodents (rats, rabbits) are all above 2000 mg/kg bw.

It is, therefore, concluded that TCPP is not classified as to its acute dermal toxicity.