Registration Dossier
Registration Dossier
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EC number: 282-968-6 | CAS number: 84501-49-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study. Only basic data given.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Limited information concerning test conditions and/or experimental methods.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium dodecyl sulphate
- EC Number:
- 205-788-1
- EC Name:
- Sodium dodecyl sulphate
- Cas Number:
- 151-21-3
- Molecular formula:
- C12H26O4S.Na
- IUPAC Name:
- sodium dodecyl sulfate
- Details on test material:
- - Name of test material (as cited in study report): Sodium laurylsulfate
- Physical state: White powder
- Analytical purity: >98% a.i.
- Lot / Batch No. : 68/3
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to guideline.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- no data
- No. of animals per sex per dose:
- 5-10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 200 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 977 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 427 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Occurred, but no detailed data.
- Clinical signs:
- Diarrhoea, spastic gait, decreased activity, lateral position, hunched posture, laboured respiration, coma, death.
- Body weight:
- Not stated.
- Gross pathology:
- Necropsy of died animals: haemorrhages in gastro-intestinal tract and vascular congestion in the liver
Necropsy of survivors: no adverse effects - Other findings:
- Not stated.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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