Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The potential of 3-((9,10-Dihydro-9,10-dioxo-4-(methylamino)-1-anthracenyl)amino)-N,N-dimethyl-N-propyl-1-Propanaminium-bromid (Bluequat-bromid)to induce contact hypersensitivity was examined using the Murine local lymph node assay. Groups of 5 female mice in each were treated with 1%, 2.5%, 5% and 10% of test substance in vehicle (Acetone/water (1:1) mixed with olive oil) for 3 daily treatments. One group of mice was treated with vehicle (Acetone/water (1:1) mixed with olive oil).On day 5, all the animals were injected with 250 µl PBS containing 21.1 µCi of H3 methyl thymidine. Auricular lymph nodes were excised and assessed for thymidine uptake.

Treatment of mice with 3-((9,10-Dihydro-9,10-dioxo-4-(methylamino)-1-anthracenyl)amino)- N,N-dimethyl-N-propyl-1-Propanaminium-bromid (Bluequat-bromid) induced a negative response, as it did not elicit at least 3 fold increase in isotope incorporation relative to the vehicle. The mean stimulation indices were 0.8, 0.6, 0.6 and 0.6 at the concentration of 1%, 2.5%, 5% and 10% respectively.


Migrated from Short description of key information:
3-((9,10-Dihydro-9,10-dioxo-4-(methylamino)-1-anthracenyl)amino)-N,N-dimethyl-N-propyl-1-Propanaminium-bromid (Bluequat-bromid) is not a skin sensitizer.

Justification for classification or non-classification