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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Valid irritation/corrosion studies with the test substance are available. In a study conducted according to OECD guideline 404 no skin reactions were observed after treatment (rabbit, Ciba-Geigy Ltd, 1984c). In a study conducted according to OECD guideline 405 only minor eye reactions were observed after treatment which were fully reversible within 48 h (rabbit, Ciba-Geigy Ltd 1984d). 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

After occlusive dermal application of 0.5 ml test article to New Zealand White rabbits for 4 h according to OECD guideline 404 (1981), skin reactions were scored 1, 24, 48 and 72 hours. Local signs (mean values from 24 to 72 hours) consisted of grade 0.00 erythema and grade 0.00 edema. The test article caused no staining of the treated skin. No signs of systemic toxicity were observed and no mortality occurred. Thus, the test substance was considered to be not irritating to skin.

0.1 ml of test article was placed into the eye of New Zealand White rabbits according to OECD 405 (1981) without rinsing. Eye reactions were scored 24, 48 and 72 hours after application. Conjunctival redness (graded 1) was seen in 3/3 animals after 24 h. All animals recovered within 48 h. Thus, the test substance was considered to be not irritating to eyes.

Justification for classification or non-classification

Dangerous Substance Directive (67/548/EEC)

The available studies are considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance was not considered to be classified for skin or eye irritation according to Annex I of Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.

Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008

The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. As a result the substance was not considered to be classified for skin or eye irritation under Regulation (EC) No. 1272/2008, as amended for the third time in Directive EC 618/2012.